I used to deal with some painful wrist and forearm stress, but this mouse was the solution. It held up for four years of heavy daily use, which is why I was comfortable buying a second one.
That's not to say the mouse isn't durable I just loved it so much that I used it for everything, including gaming, which far surpassed the click limit. Logitech's MX Ergo trackball mouse is a personal all-time favorite, to the point that I've now purchased a second one after wearing out the first. $100 at Amazon $100 at Best Buy $100 at B&H
